The effect of aging on T-regulatory cell frequency in HIV infection.

TitleThe effect of aging on T-regulatory cell frequency in HIV infection.
Publication TypeJournal Article
Year of Publication2009
AuthorsTenorio AR, Spritzler J, Martinson J, Gichinga CN, Pollard RB, Lederman MM, Kalayjian RC, Landay AL
JournalClin Immunol
Volume130
Issue3
Pagination298-303
Date Published2009 Mar
ISSN1521-7035
KeywordsAdult, Aging, CD4 Lymphocyte Count, Cell Line, Tumor, HIV Infections, HIV-1, Humans, Middle Aged, T-Lymphocytes, Regulatory, Young Adult
Abstract

T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV(+) subjects had a total T-reg percent that is 2.8% (p=0.02) higher than among younger HIV(+), older HIV(-) and younger HIV(-) subjects. In HIV(+) subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r=-0.45, p=0.002) and Candida (r=-0.43, p=0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV(+) subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV(+) population and may play a role in the accelerated disease progression seen in older HIV-infected persons.

DOI10.1016/j.clim.2008.10.001
Alternate JournalClin. Immunol.
PubMed ID19008157
PubMed Central IDPMC2662473
Grant ListAI068636 / AI / NIAID NIH HHS / United States
AI38858 / AI / NIAID NIH HHS / United States
U01 AI038858 / AI / NIAID NIH HHS / United States
U01 AI038858-029001 / AI / NIAID NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
U01 AI068634-01 / AI / NIAID NIH HHS / United States
U01 AI068636 / AI / NIAID NIH HHS / United States
U01 AI068636-01 / AI / NIAID NIH HHS / United States
U01 AI069471 / AI / NIAID NIH HHS / United States
U01 AI069471-02 / AI / NIAID NIH HHS / United States
U01 AI069501 / AI / NIAID NIH HHS / United States
U01 AI069501-02 / AI / NIAID NIH HHS / United States
U01-AI068634 / AI / NIAID NIH HHS / United States
U01-AI069471 / AI / NIAID NIH HHS / United States
U01-AI069501 / AI / NIAID NIH HHS / United States