Treatment responses in antiretroviral treatment-naive premenopausal and postmenopausal HIV-1-infected women: an analysis from AIDS Clinical Trials Group Studies.

TitleTreatment responses in antiretroviral treatment-naive premenopausal and postmenopausal HIV-1-infected women: an analysis from AIDS Clinical Trials Group Studies.
Publication TypeJournal Article
Year of Publication2009
AuthorsPatterson KB, Cohn SE, Uyanik J, Hughes M, Smurzynski M, Eron JJ
JournalClin Infect Dis
Volume49
Issue3
Pagination473-6
Date Published2009 Aug 1
ISSN1537-6591
KeywordsAcquired Immunodeficiency Syndrome, Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Female, HIV-1, Humans, Middle Aged, Postmenopause, Premenopause, Treatment Outcome, United States, Viral Load
Abstract

Menopause may affect antiretroviral treatment (ART) response. Immunologic and virologic responses to ART were compared in 220 premenopausal and 47 postmenopausal women enrolled in 2 studies involving ART-naive persons. Changes in CD4 counts or human immunodeficiency virus type 1 RNA levels were similar at 24, 48, and 96 weeks after treatment initiation. ART-naive women should respond to ART regardless of menopausal status.

DOI10.1086/600398
Alternate JournalClin. Infect. Dis.
PubMed ID19555288
PubMed Central IDPMC2712125
Grant ListAI-68636 / AI / NIAID NIH HHS / United States
K23 AI077355 / AI / NIAID NIH HHS / United States
K23 AI077355-01 / AI / NIAID NIH HHS / United States
P30 AI050410 / AI / NIAID NIH HHS / United States