Antiretroviral drug resistance in HIV-1-infected patients experiencing persistent low-level viremia during first-line therapy.

TitleAntiretroviral drug resistance in HIV-1-infected patients experiencing persistent low-level viremia during first-line therapy.
Publication TypeJournal Article
Year of Publication2011
AuthorsTaiwo B, Gallien S, Aga E, Ribaudo H, Haubrich R, Kuritzkes DR, Eron JJ
JournalJ Infect Dis
Volume204
Issue4
Pagination515-20
Date Published2011 Aug 15
ISSN1537-6613
KeywordsAdult, Drug Resistance, Viral, Female, HIV Infections, HIV-1, Humans, Male, Mutation, Retrospective Studies, Viremia
Abstract

Population sequencing was performed for persons identified with persistent low-level viremia in 2 clinical trials. Persistent low-level viremia (defined as plasma HIV-1 RNA level >50 and <1000 copies/mL in at least 2 determinations over a 24-week period, after at least 24 weeks of antiretroviral therapy) was observed in 65 (5.6%) of 1158 patients at risk. New resistance mutations were detected during persistent low-level viremia in 37% of the 54 evaluable cases. The most common mutations were M184I/V (14 cases), K103N (9), and M230L (3). Detection of new mutations was associated with higher HIV-1 RNA levels during persistent low-level viremia.

DOI10.1093/infdis/jir353
Alternate JournalJ. Infect. Dis.
PubMed ID21791652
PubMed Central IDPMC3203388
Grant List1 U01 AI068634 / AI / NIAID NIH HHS / United States
AI36214 / AI / NIAID NIH HHS / United States
AI50410 / AI / NIAID NIH HHS / United States
AI69423 / AI / NIAID NIH HHS / United States
AI69432 / AI / NIAID NIH HHS / United States
K24 AI064086 / AI / NIAID NIH HHS / United States
K24 AI064086-06 / AI / NIAID NIH HHS / United States
K24 RR061482 / RR / NCRR NIH HHS / United States
K24-AI064086 / AI / NIAID NIH HHS / United States
M01 RR000827 / RR / NCRR NIH HHS / United States
P30 AI036214 / AI / NIAID NIH HHS / United States
P30 AI050410 / AI / NIAID NIH HHS / United States
RR025747 / RR / NCRR NIH HHS / United States
U01 AI 068636 / AI / NIAID NIH HHS / United States
U01 AI069432 / AI / NIAID NIH HHS / United States
UM1 AI069423 / AI / NIAID NIH HHS / United States