ACTG Adds First Polyclonal Antibody to ACTIV-2 Outpatient Treatment Study for COVID-19

April 21, 2021

The AIDS Clinical Trials Group (ACTG), the largest global HIV research   network, today announced the addition SAB-185, a polyclonal antibody therapy, to the COVID-19 outpatient treatment study, ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial. ACTIV-2 includes both phase 2 and phase 3 evaluations of multiple investigational agents for treating early, symptomatic COVID-19 in a single trial. For information about enrolling in the trial, please visit the study website.

ACTG to Present 24 New Studies at CROI 2021

March 3, 2021

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, will present four oral and 20 scientific spotlight sessions at the Conference on Retroviruses and Opportunistic Infections (CROI 2021) held virtually, March 6-10. CROI is one of the premier global HIV research conferences and ACTG’s robust presence at the meeting demonstrates its continued leadership in HIV and related fields.

ACTG Adds Four Promising New Therapies to ACTIV-2 Outpatient Treatment Study

February 12, 2021

Los Angeles, Calif. – The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, today announced the addition of four new promising therapies to the COVID-19 outpatient treatment study, ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial. These additional agents represent a variety of treatment modalities, including a rapid infusion, an intramuscular injection, an inhalant, and an oral agent. ACTIV-2 includes both phase 2 and phase 3 evaluations of multiple investigational agents for treating early, symptomatic COVID-19 in a single trial. For information about enrolling in the trial, please visit the study website.

ACTG Adds New Agent to ACTIV-2 Trial Investigating Early COVID-19 Treatments

January 5, 2021

Los Angeles, Calif. – The AIDS Clinical Trials Group (ACTG), the largest global HIV research   network, today announced the addition of a new agent to the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial. This phase 2 study, which is being led by the ACTG, will evaluate the combination of the two monoclonal antibodies BRII-196 and BRII-198 to treat early COVID-19. ACTIV-2 includes both phase 2 and phase 3 evaluations of multiple promising investigational agents for treating early, symptomatic COVID-19 in a single trial. For information about enrolling in the trial, please visit the study website.

NIH Re-Funds ACTG for the Next Seven Years

November 30,2020

Los Angeles, Calif. – The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, has been re-funded for the next seven years by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and collaborating NIH Institutes. The group is led by Judith Currier, M.D., M.Sc, Professor of Medicine at the University of California, Los Angeles (UCLA) and Joseph Eron M.D., Professor of Medicine, University of North Carolina. The Operations Center is based at UCLA.

ACTG Presents Data Showing Minimal Monitoring Approach to Hepatitis C Treatment is Safe and Successful at AASLD’s 2020 Liver Meeting

November 16, 2020

Los Angeles, Calif. – The AIDS Clinical Trials Group (ACTG), the world’s largest and longest established HIV research network, presented today The “Keep it Simple and Safe” Approach to HCV Treatment: Primary Outcomes from the ACTG A5360 (MINMON) Study at AASLD’s virtual 2020 Liver Meeting. The study found that in a diverse, global patient population, a minimal monitoring (MINMON) approach to hepatitis C treatment was safe and achieved comparable sustained virologic response (SVR) to current standard of care.

ACTG Announces Launch of Novel Clinical Trial Testing Multiple Therapeutics to Treat COVID-19

August 4, 2020

Los Angeles, Calif. – The AIDS Clinical Trials Group (ACTG), the world’s largest and longest established HIV research network, today announced the initiation of the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial, which will be conducted by the ACTG. ACTIV-2 includes both phase 2 and phase 3 evaluations of multiple promising investigational agents for treating early COVID-19 in a single trial. There is currently no approved vaccine or therapeutic to prevent or treat COVID-19. For information about enrolling in the trial, please click here.

ACTG Launches Clinical Trial Testing Treatment for COVID-19

May 14, 2020

Los Angeles, Calif. – The AIDS Clinical Trials Group (ACTG), the world’s largest and longest established HIV research network, today announced the initiation of ACTG 5395, a clinical trial to evaluate whether the drug combination hydroxychloroquine and azithromycin can prevent hospitalization and death from COVID-19 (which is caused by infection with the virus SARS-CoV-2). There is currently no approved vaccine or therapeutic to prevent or treat COVID-19, which has been spreading worldwide since cases were first reported in December 2019 in Wuhan, Hubei Province, China.

ACTG TO PRESENT NEW HIV AND TB RESEARCH AT CROI 2020

March 3, 2020

Los Angeles, Calif. – The AIDS Clinical Trials Group (ACTG), the world’s largest and longest-established HIV research network, will make 28 presentations at the Conference on Retroviruses and Opportunistic Infections (CROI 2020) held in Boston, March 8-11. ACTG investigators will present data in oral presentations and themed discussions on the impact of chronic antiretroviral therapy (ART) on a novel metric of the HIV reservoir, predictors of multidrug resistant tuberculosis (MDR-TB) in resource-limited settings, findings from the first HIV cure trial that exclusively enrolled women, and interactions between contraceptives and TB drugs and the vaginal microbiome.

ACTG HIV RESERVOIRS COHORT STUDY DEMONSTRATES THAT PERSISTENT HIV DNA IN SPINAL FLUID MAY BE ASSOCIATED WITH COGNITIVE CHALLENGES

July 15, 2019

Los Angeles, Calif. – Investigators from the AIDS Clinical Trials Group (ACTG), the world’s largest and longest-established HIV research network, today announced that the Journal of Clinical Investigation published new findings from the ACTG HIV Reservoirs Cohort Study (A5321). The study found that HIV DNA remained in the cerebrospinal fluid of half of participants with well-managed HIV (virologic suppression in the plasma), confirming that the central nervous system (CNS) is a major reservoir for latent HIV. Individuals who harbored HIV DNA in the cerebrospinal fluid were more likely than other study participants to experience cognitive deficits on neurocognitive testing.

ACTG PRESENTS NEW RESEARCH ON HIV AND TB, CO-MORBIDITIES, TREATMENT PARADIGMS, AND CURE AT CROI 2019

February 26, 2019

The AIDS Clinical Trials Group (ACTG), the world’s largest and longest-established HIV research network, funded by NIAID at the U.S. NIH, will make 11 oral and 19 poster presentations at CROI 2019 (Seattle, March 4-7). Several have the potential to influence clinical practice and guidelines for care.
“For more than 30 years, the ACTG has been at the forefront of research to treat HIV and its coinfections and comorbidities,“ said ACTG Chair Judith Currier, M.D., MSc of the University of California Los Angeles. “These studies represent the breadth of ACTG investigations and offer important insights into the treatment of MDR-TB, how to approach antiretroviral treatment in resource-limited settings, and strategies to address chronic complications of HIV.”