The Leadership and Operations Center (LOC), Administrative Core has administrative and fiduciary responsibility for managing all funds awarded to the LOC and Laboratory Center (LC). The Administrative Core was established within the Division of Infectious Diseases at Brigham and Women’s Hospital (BWH) in January, 2012. The Administrative Core is responsible for developing budgets; negotiating and executing contracts on behalf of the LOC and LC; monitoring spending and financial activity on all LOC and LC awards. The Administrative Core reports to the ACTG Network Leadership Steering Committee (LSC) and provides administrative and financial support to the ACTG Executive Committee (AEC). It also serves as the archival home for all LOC and LC administrative and fiduciary records. The Administrative Core prepares and submits annual progress reports and other administrative reports to DAIDS; manages conference support for annual ACTG network meetings and leadership and scientific retreats; maintains the financial conflict of interest (FCOI) disclosure program; tracks ACTG publications and ensures compliance with NIH open access requirements; and coordinates external communications, social media, and press releases. The Administrative Core is led by the LOC Executive Director, Aisha Zaidi, and comprises Grants & Contracts, Budget & Finance, and Leadership Support teams.