ACTG Abstract Presentations 2018 CROI

ACTG Abstract Presentations 2018 Conference on Retroviruses and Opportunistic Infections

Oral Presentations

A5225
Lalloo U., Larsen R., Aberg J., Hogg E., Komarow L., Clifford D., Pillay S., Langat D., Bukuru A., Mave V., Supparatpinyo K., Samaneka W. Higher High Dose Fluconazole for the Treatment of Cryptococcal Meningitis, Results from ACTG A5225. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5257
Gandhi M., Ofotokun I., Bacchetti P., Jin C., Ribaudo H., Haas D., Sheth A., Hochster H., Phung N., Kuncze K., Louie A., Okochi H., Landovitz R., Lennox J., Currier J. Hair antiretroviral (ARV) levels strongly predict virologic outcomes in ACTG A5257. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5264
Campbell T., Kang M., Umbleja T., Krown S., Bukuru A., Martin J., Godfrey C., Nyirenda M., Busakhala N., Borok-Williams M., Langat D., Hoagland B., Mwelase N., Hosseinipour M. Predictors of KS-IRIS in mild/moderate AIDS-KS during ART in low-resource settings. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5279
Swindells S., Ramchandani R., Gupta A., Benson C., Leon-Cruz J., Omoz-Oarhe A., Juste M., Lama J., Badal-Faesen S., Moran L., Fletcher C., Nuermberger E., Chaisson R. One month of rifapentine/isoniazid to prevent TB in people with HIV: Brief-TB/A5279. Accepted by Conference, 01/25/2018. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5282
Wilkin T., Matining R., Sahasrabuddhe V., Chen H., Masih R., Mngqibisa R., Rassool M., Mbilizi Y., Magure T., Riviere C., Asmelash A., Bhosale R., Michelow P., Godfrey C., Firnhaber C. ACTG 5282: HPV test&treat vs. cytology-based cervical cancer prevention in HIV+ women. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5288
Grinsztejn B., Hughes M., Ritz J., Salata R., Mugyenyi P., Hogg E., Wieclaw L., Gross R., Godfrey C., Kumarasamy N., Kanyama C., Mellors J., Wallis C., Collier A. Results of A5288: A Strategy Study in RLS for 3rd Line ART Candidates. Accepted by Conference, 01/25/2018. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5314
Hsue P., Ribaudo H., Deeks S., Lederman M., Fichtenbaum C., Luetkemeyer A., Daar E., Rodriguez B., Taiwo B., Haas D., Johnson V., Stein J., Currier J. Safety and impact of LDMTX on immune activation and endothelial function in treated HIV: ACTG 5314. Accepted by Conference, 12/19/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5315
McMahon D., Zheng L., Cyktor J., Aga E., Macatangay B., Rinaldo C., Godfrey C., Para M., Hogg E., Hesselgesser J., Gandhi R., Mellors J. Single romidepsin infusions do not increase HIV expression in persons on ART (A5315) . Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5316
Scarsi K., Cramer Y., Gingrich D., Rosenkranz S., Aweeka F., Coombs R., Zorrilla C., Coughlin K., Moran L., Berzins B., Godfrey C., Cohn S. Vaginal contraceptive hormone exposure profoundly altered by EFV- and ATV/r-based ART. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5321
Spudich S., Gandhi R., Cyktor J., Lalama C., Bosch R., Macatangay B., Rinaldo C., Robertson K., Collier A., Godfrey C., Hogg E., Eron J., McMahon D., Mellors J. HIV-1 Persists in Cerebrospinal Fluid Mononuclear Cells in Half of HIV-infected Individuals on Long-term Antiretroviral Therapy. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5349
Podany A., Sizemore E., Chen M., Martinson N., Badal-Faesen S., Dawson R., Miyahara S., Whitworth J., Kurbatova E., Chaisson R., Dorman S., Nahid P., Dooley K., Swindells S. Efavirenz pharmacokinetics in HIV/TB coinfected persons receiving rifapentine. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

Poster Presentations

A5208
Boltz V., Shao W., Halvas E., McIntyre J., Schooley R., Lockman S., Currier J., Sawe F., Hogg E., Hughes M., Kearney M., Coffin J., Mellors J. Rare HIV Variants with Linked Dual-Class Resistance Are Associated with ART Failure. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018

A5257 NWCS 417
El-Kamary V., Moser C., Currier J., Brown T., Johnston L., Hillman C., Hunt P., McComsey G. Lower pretreatment gut integrity independently associated with fat gains on antiretrovirals. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5308
Li J., Segal F., Bosch R., Lalama C., Tressler R., Van Dam C., Keefer M., Carrington M., Lichterfeld M., Kuritzkes D., Yu X., Landay A., Sax P. ART reduces T cell activation and immune exhaustion markers in HIV controllers. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5314
Tawakol A., Ishai A., McKhann A., Solomon D., Ribaudo H., Stein J., Currier J., Lederman M., Ridker P., Deeks S., Grinspoon S., Fayad Z., Hsue P. Impact of LDMTX on arterial inflammation in persons with treated HIV. Accepted by Conference, 01/29/2018. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5321
Keating S., Jones R., Lalama C., Bosch R., McMahon D., Hampton D., Hogg E., Cyktor J., Eron J., Mellors J., Busch M., Gandhi R. HIV antibody and T cell responses on ART are associated with HIV DNA but not RNA . Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018
Macatangay B., Gandhi R., McMahon D., Lalama C., Bosch R., Cyktor J., Hensel C., Hogg E., Borowski L., Eron J., Mellors J., Rinaldo C. Persistence of CD4+PD-1high T cells Despite Long-Term Suppressive ART. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.
Robertson K., Bosch R., Spudich S., Gandhi R., Cyktor J., Mar H., Macatangay B., Lalama C., Rinaldo C., Collier A., Godfrey C., Eron J., McMahon D., Mellors J. Poorer neurocognitive performance is associated with HIV in CSF despite long-term ART. Accepted by Conference, 01/25/2018. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5322
Kelly S., Wu K., Tassiopoulos K., Erlandson K., Koletar S., Palella F. Functional status associated with cardiovascular disease and diabetes risk in HIV+ adults. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5322 DACS 334
Chow F., Wu K., Tassiopoulos K., Berzins B., Robertson K., Taiwo B. Cardiovascular risk factors associated with neurocognitive impairment differ by sex. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5325
Lin N., Macatangay B., Chan E., Ribaudo H., Klingman K., Boone L., Li J., Kane M., Aweeka F., Rinaldo C., McGowan I., Kuritzkes D., Kwon D. A controlled study to evaluate the immunologic effect of isotretinoin on HIV-1 infection. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5340
Bar K., Salantes B., Zheng Y., Mampe F., Beg S., Lai J., Tressler R., Koup R., Hoxie J., Mohsin M., Siliciano R., Siliciano J., Overton E., Tebas P. A5340: Brief ATI does not alter the size or composition of the latent HIV-1 reservoir. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5349
Podany A., Sizemore E., Chen M., Martinson N., Badal-Faesen S., Dawson R., Miyahara S., Whitworth J., Kurbatova E., Chaisson R., Dorman S., Nahid P., Dooley K., Swindells S. Efavirenz pharmacokinetics in HIV/TB coinfected persons receiving rifapentine. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

A5352s
Presti R., Kitch D., Andrade A., Landay A., Jacobson J., Wilson C., Yeh T., Estes J., Deleage C., Klingman K., Utay N., Overton E., Brenchley J., Williams B. Effects of Probiotic Visbiome ES on Colonic Mucosal CD4 Cells; Results from A5352s. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

NWCS 275
Haas D., Bradford Y., Verma A., Verma S., Pendergrass S., Eron J., Gulick R., Riddler S., Sax P., Campbell T., Daar E., Morse G., Acosta E., Ritchie M. Brain neurotransmitter genomics and efavirenz central nervous system (CNS) effects. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

NWCS 329
Hoenigl M., Moser C., Funderburg N., Bosch R., Kantor A., Zhang Y., Eugen-Olsen J., Finkelman M., Landay A., Lederman M., Weibel S. Novel biomarkers predictive of non-AIDs events during art-mediated viral suppression. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018

NWCS 371
Strongin Z., Sharaf R., VanBelzen D., Jacobson J., Connick E., Volberding P., Skiest D., Gandhi R., Kuritzkes D., O'Doherty U., Li J. Short-term ART interruption has little effect on Levels of integrated proviral DNA. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

NWCS 380
Sharaf R., Lee G., Sun X., Aga E., Bosch R., Gandhi R., Jacobson J., Acosta E., Kuritzkes D., Lederman M., Yu X., Lichterfeld M., Li J. HIV proviral landscape with post-treatment control and host immune responses. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.
Namazi G., Fajnzylber J., Aga E., Bosch R., Acosta E., Jacobson J., Volberding P., Skiest D., Mitsuyasu R., Schooley R., Collier A., Routy J., Walker B., Li J. The CHAMP Cohort: Post-treatment controllers identified from 9 clinical studies. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.

NWCS 399
Lake J., Moser C., Johnston L., Magyar C., Nelson S., Erlandson K., Brown T., McComsey G. Fat quality is independently associated with cardiometabolic risk in HIV infection. Accepted by Conference, 11/14/2017. 2018 25th Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA, 03/04/2018 - 03/07/2018.